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Title   대장암에 대한 5-Fluorouracil 지속주입 및 Mitomycin-C ( FM ) 복합화학요법의 치료효과 ( 5-Fluorouracil Continuous Infusion and Mitomycin-C ( FM ) Combination Chemotherapy for Metastatic or Recurrent Colorectal Cancer )
Publicationinfo   1987 Jan; 019(02): 101-107.
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Abstract   Between March, 1983 and June, 1986, 64 patients with metastatic or recurrent colorectal cancer were treated with a combination chemotherapy consisting of 5-fluorouracil (5-FV), 1,000 mg/m iv continuous infusion over .12 hours on day 1-5; mitomycin-C, 10 mg/m iv on day 1; cycled every 4 weeks. Among 46 patients with measurable lesions, none achieved complete remission and 5 (11%) achieved partial remissions. The median duration of remission was 31 weeks. Overall median survival was 49 weeks for all patients; 65 weeks for patients with remission; 51 weeks for those with stable disease; and 31 weeks for those with progressive disease, Greater response rates were observed in patient groups with age over 50, performance status 0-1, no previous history of chemotherapy, initial CEA level less than 10 ng/ml, or metastatic sites of lymph node, than in respective comparative patient groups. But, these differences did not achieved statistical significance. Toxicity was common, but generally mild to moderate and rapidly reversible.
저 자   강윤구(Keun Chil Park),윤성수(Sung Soo Yoon),이재훈(Jae Hoon Lee),김승택(Seung Taek Kim),방영주(Yung Jue Bang),김노경(Noe Kyeong Kim),박재갑(Jae Gahb Park),이건욱(Kuhn Uk Lee),홍성국(Sung Kuk Hong),최국진(Kuk Jin Choe),김수태(Soo Tae Kim),하성환(Sung Whan Ha),박찬일(Charn Il Park),